Exciting news from the FM@H project - first in vitro validation comes up with hits!
We've had our first major success from the FightMalaria@Home project. After analyzing the data generated in the first phase (docking all the 400 MalariaBox compounds against all models), we have ranked lists of potential inhibitors for each receptor. But are these real? This is the kind of question that keeps us up at night.
Now we can rest easy - we've tested the top 20 hits using a model of the Plasmodial form of HDAC (histone deacetylase) in a laboratory (Dr Marian Brennan, RCSI, Dublin), and found THREE new inhibitors! So that's just one of the 1,500 receptors that we're docking, using only the best docking results (i.e. only the 20 best ligands).
It's a fantastic result, giving us hope that there are other gems waiting to be found in the data that you've generated on your home PCs!
Well done everyone!!!!!
ps: We're in the process of writing up a manuscript for publication in an open-access journal, so you'll be able to read about all the details, and download all the data generated from FM@H, once we've survived the peer review process.
16 May 2013, 9:41:49 UTC
No new tasks for 24 hours
We are going to turn off the work generator for 24 hours to clear the backlog of results.
Thanks to everyone who participated in the challenge.
2 May 2013, 17:34:49 UTC
One of the tables in our task database has been corrupted. As a result we will be down for at least a few hours while we restore from a recent backup and ensure that we aren't missing anything. We will be back up and running soon.
10 Apr 2013, 12:50:31 UTC
We found a small bug in the assimilator daemon which prevented assimilation of WUs for about 2.5 days. We are now turning off the work generator to allow the assimilator to catch up. We will likely be up and running again at this time tomorrow.
2 Apr 2013, 16:46:33 UTC
New workunits in 24 hours
We will be deploying new workunits in the next 24 hours. Between now and then you will not be able to receive new WUs.
24 Mar 2013, 18:05:44 UTC
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