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GoFundMe server appeal
Dear all,
After a recent suggestion from BOINC users (http://boinc.ucd.ie/fmah/forum_thread.php?id=93), we're going to attempt crowdfunding for a new server to help us cope with the increased load now that ~16,000 computers are connected to our project in 127 countries!
If you'd like to contribute, please visit:
http://www.gofundme.com/FightMalariaAtHome
Thanks!
Ant 11 Jun 2013, 11:05:59 UTC · Comment

No new tasks for 24 hours
Hi Guys,
The server is overloaded at the moment. I'm going to turn off the work generator for 24-48 hours to let the assimilator catch up.
Hopefully it will be back up before the weekend is over.
Thanks,
Kevin 24 May 2013, 15:57:03 UTC · Comment

Exciting news from the FM@H project - first in vitro validation comes up with hits!
Dear all,
We've had our first major success from the FightMalaria@Home project. After analyzing the data generated in the first phase (docking all the 400 MalariaBox compounds against all models), we have ranked lists of potential inhibitors for each receptor. But are these real? This is the kind of question that keeps us up at night.
Now we can rest easy - we've tested the top 20 hits using a model of the Plasmodial form of HDAC (histone deacetylase) in a laboratory (Dr Marian Brennan, RCSI, Dublin), and found THREE new inhibitors! So that's just one of the 1,500 receptors that we're docking, using only the best docking results (i.e. only the 20 best ligands).
It's a fantastic result, giving us hope that there are other gems waiting to be found in the data that you've generated on your home PCs!
Well done everyone!!!!!
ciao,
Ant
ps: We're in the process of writing up a manuscript for publication in an open-access journal, so you'll be able to read about all the details, and download all the data generated from FM@H, once we've survived the peer review process.
16 May 2013, 9:41:49 UTC · Comment

No new tasks for 24 hours
Hi everyone,
We are going to turn off the work generator for 24 hours to clear the backlog of results.

Thanks to everyone who participated in the challenge.
Kevin 2 May 2013, 17:34:49 UTC · Comment

Database Problem
Hi guys,
One of the tables in our task database has been corrupted. As a result we will be down for at least a few hours while we restore from a recent backup and ensure that we aren't missing anything. We will be back up and running soon.
Thanks,
Kevin 10 Apr 2013, 12:50:31 UTC · Comment

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